Autoimmune Diseases are a group of otherwise unrelated disorders that are caused by the Inflammation and destruction of tissues within the body by the body's own Antibodies (Auto-Antibodies) and T-Lymphocytes. Some evidence strongly suggests that Autoimmune Diseases are the result of Hydrolases escaping from Lysosomes whose membranes have been ruptured by Lipid Peroxidation and other causes - these Hydrolases then combine with and denature normal endogenous Proteins (in effect, converting them into Antigens) - to which the body reacts by producing Antibodies.
Types of Autoimmune Diseases
Organ-Specific Autoimmune Diseases are Autoimmune Diseases that involve specific organs of the body. They include:
Acute Kidney Allograft Rejection
some cases of (unexplained) Miscarriage
Systemic Autoimmune Diseases are Autoimmune Diseases that involve various regions of the body. They include:
Alzheimer’s Disease (strongly speculated)
Diabetes Mellitus Type 1
Inflammatory Joint Diseases
Male Pattern Baldness
Autoimmune Diseases are more prevalent in women than in men.
These Substances Prevent/Alleviate Autoimmune Diseases
Glutathione is able to stop the production of Cytokines when they are being produced in the excessive amounts that cause Autoimmune Diseases - it is recommended that Cysteine and Glutamine be supplemented to stimulate the production of Glutathione within the body as Glutathione is poorly absorbed orally.
These Substances Enhance the Function of Glutathione
Cysteine is an essential precursor for the endogenous production of Glutathione:
- However, only a very small quantity of supplemental L-Cysteine is utilized in the endogenous manufacture of Glutathione (due to the rapid oxidation of L-Cysteine to Cystine).
- Alternatively, the majority of exogenous N-Acetyl-Cysteine (NAC) is converted to Glutathione (the NAC form of Cysteine, unlike L-Cysteine, is not oxidized to Cystine).
- Of the several precursors for Glutathione, Cysteine is believed to be the most important as the other precursors (Glycine and Glutamic Acid) are generally not deficient. This means that Cysteine is generally the rate-limiting factor in Glutathione production.
Glutamine is integral to the production of Glutathione within the body (Glutamic Acid is extracted from Glutamine's chemical structure within the Liver for incorporation into the Glutathione molecule).
Glycine is an essential component of Glutathione.
Methionine facilitates the production of Glutathione (and prevents the decline in Glutathione levels that are associated with the progression of the Aging Process).
S-Adenosylmethionine (SAM) is essential for the endogenous production of Glutathione.
Taurine supplementation increases platelet Glutathione levels.
Butylated Hydroxytoluene (BHT) increases the body’s Glutathione levels.
Auxins (Plant Hormones)
Indole-3-Carbinol stimulates the endogenous production of Glutathione by Liver Cells (hepatocytes).
Glutathione Reductase helps to maintain Glutathione in its active state.
Glutathione-S-Transferase enhances the function of Glutathione - it catalyzes the reaction of Glutathione with acceptor molecules of various toxins, thereby functioning as a key enzyme in the detoxification of various substances.
Glutathione Synthetase catalyzes the production of Glutathione, Adenosine Diphosphate (ADP) and Orthophosphate from Gamma Glutamyl Cysteine, Adenosine Triphosphate (ATP) and Glycine.
Dehydroepiandrosterone (DHEA) stimulates the endogenous production of Glutathione by Liver Cells (hepatocytes).
Melatonin increases the endogenous production of Glutathione:
- Melatonin inhibits the depletion of Glutathione in the Liver that is caused by Cadmium accumulation.
Germanium increases the body's Glutathione levels.
Magnesium facilitates the endogenous synthesis of Glutathione and Magnesium deficiency often results in low serum Glutathione levels.
Selenium facilitates the endogenous production of Glutathione:
- Sodium Selenite (form of Selenium) stimulates the endogenous production of Glutathione by Liver Cells (hepatocytes).
Sulfur is an essential component of Glutathione.
Zinc facilitates the endogenous production of Glutathione and Zinc deficiency results in lowered plasma Glutathione levels.
Ellagic Acid stimulates the endogenous manufacture of Glutathione.
Curcumin stimulates the endogenous production of Glutathione by Liver Cells (hepatocytes).
Ellagic Acid recycles Glutathione.
Quercetin recycles Glutathione.
Silymarin inhibits the depletion of Glutathione in the Liver and can increase Liver Glutathione levels by up to 35%.
Whey Protein (when correctly processed) causes sustained increases in the body’s Glutathione levels.
Lipoic Acid increases intracellular Glutathione levels by 30% - 70%.
- Lipoic Acid (1% cream/lotion applied topically) increases the Glutathione content of the Skin.
Vitamin B2 recycles oxidized, degraded Glutathione into fresh active Glutathione:
- Vitamin B2 increases Glutathione levels in Sickle Cell Anemia patients.
Vitamin B6 enhances the function of Glutathione.
Vitamin C increases Glutathione levels.
Vitamin E enhances the function of Glutathione.
These Foods Enhance the Function of Glutathione
Garlic increases the body’s levels of Glutathione and reduces levels of oxidized Glutathione.
Globe Artichoke prevents the destruction of the Liver’s Glutathione content by various oxidative agents.
Dietary Sources of Glutathione
(mg of Glutathione per 100 grams)
Note that Cooking destroys ALL Glutathione present in these dietary sources.
Fruits: Apples, Avocado, Grapefruit, Watermelon
Vegetables: Broccoli, Carrots. Tomatoes, Spinach, Asparagus
The Following Substances Interfere with Glutathione
Cadmium decreases the level of Glutathione present in the Liver.
Excessive consumption of Copper inhibits the production of Glutathione.
Excessive consumption of Iron inhibits the production of Glutathione.
Hydrogen Sulfide (produced within the Digestive Tract by Detrimental Bacteria) destroys Glutathione.
Hydrogen Peroxide destroys Glutathione.
Excessive consumption of Polyunsaturated Fatty Acids inhibits the production of Glutathione.
Helicobacter pylori causes the depletion of the body’s Glutathione reserves.
Mercury causes the depletion of Glutathione.
Aspirin causes the depletion of Glutathione.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) cause the depletion of Glutathione.
When Paracetamol is metabolized in the Liver by Cytochrome P-450, a toxic by-product is generated that reacts with and destroys Glutathione.
These Factors Interfere with Glutathione
Exposure of the Skin to Ultra-Violet Radiation causes the depletion of Glutathione from the Skin.
Intensive Exercise or Endurance Exercise lowers the body’s endogenous Glutathione levels (due to excessive Exercise generating excessive quantities of Free Radicals which Glutathione then attempts to “mop up” - this quenching of excessive Free Radicals results in depletion of Glutathione):
- A session of intensive Exercise can deplete Muscle Glutathione levels by up to 40% and can deplete Liver Glutathione levels by up to 80%.
Food Processing Techniques
The Heat generated during Cooking destroys all Glutathione present in dietary sources.
Alcohol (ethanol) causes the depletion of Glutathione.
Most agree that Glutathione is not bioavailable when supplemented orally as it quickly breaks down into its individual constituent Amino Acids. Injectable Glutathione is presumed to be more bioavailable to the body than orally-administered Glutathione.
The best way to introduce Glutathione into the body is via Cysteine (or N-Acetyl Cysteine) and Glutamine supplementation (as these nutrients contribute to the endogenous production of Glutathione within the Liver).
Many people use 50 - 250 mg of Glutathione per day for the purpose of deriving its Antioxidant properties.
The most commonly recommended dosage of oral supplemental Glutathione for therapeutic purposes is 500 mg per day (notwithstanding the fact that exogenous Glutathione is not very bioavailable to the body when administered orally).
Glutathione is non-toxic, even in very high doses.
Endogenous Glutathione Levels
The average plasma Glutathione levels of young persons (average age 24) is 0.54 mmol (micromoles) per liter. The average plasma Glutathione levels of elderly persons (average age 71) is 0.29 mmol (micromoles) per liter.
Practical Considerations for Glutathione Supplementation
Oral Glutathione supplements are relatively expensive and not readily bioavailable when consumed orally. It is probably more practical (and more economical) to supplement with the less expensive Cysteine.
Enzyme Therapy (i.e. involving multiple Enzymes, especially Proteolytic Enzymes) break up (degrade) the Immune Complexes that are implicated in Autoimmune Diseases. Specific Enzymes that are commonly utilized during Enzyme Therapy to degrade Immune Complexes include:
USE LIFE-CHECK ENZYME/PRE/PROBIOTIC FORMULA
Progesterone (natural Progesterone cream applied topically) alleviates many Autoimmune Diseases in women (the underlying mechanism for this effect is speculated to be the ability of Progesterone to counteract estrogens dominance which has been implicated as a cause of many Autoimmune Diseases in women).
Alpha-Linolenic Acid (LNA) suppresses the autoimmune response which may help to prevent Autoimmune Diseases.
Beta-Sitosterol helps to control Autoimmune Diseases.
Beta-Sitosterol Glycoside helps to control Autoimmune Diseases.
Magnesium Bicarbonate (1.5 liters of Magnesium Bicarbonate-containing Water per day for at least six weeks) can cause the remission of Autoimmune Diseases.
Selenium may be useful for the treatment and prevention of Autoimmune Diseases.
Gelatin Hydrolysates suppresses some T-Lymphocyte-mediated Autoimmune Diseases.
Methylsulfonylmethane (MSM) helps to prevent Autoimmune Diseases.
Vitamin D helps to prevent Autoimmune Diseases.
Supplemental Vitamin E improves the condition of many people afflicted with various Autoimmune Diseases.
These Foods/Supplements Help to Prevent Autoimmune Diseases
Oils (dietary Oils)
Regular consumption of Omega Oils helps to prevent Autoimmune Diseases.
These Factors Alleviate Autoimmune Diseases
Diet Restriction alleviates Autoimmune Diseases by normalizing the body's production of B-Lymphocytes.
Orthodox Medical Treatments for Autoimmune Diseases
Immunosuppressive Drugs are utilized in the treatment of some types of Autoimmune Diseases:
Pharmaceutical Glucocorticosteroids (e.g. Prednisone) are often prescribed in the treatment of various Autoimmune Diseases in order to suppress the Immune response:
Caution: The above possess numerous undesirable side effects.
These Substances Cause Autoimmune Diseases
Immune System Chemicals
Immune Complexes (formed by the combination of Antigens with specific Antibodies) are strongly speculated to initiate the autoimmune reactions that are implicated in Autoimmune Diseases.
Excessive production of Interleukin 6 (IL-6) has been implicated in Autoimmune Diseases.
Persons afflicted with Autoimmune Diseases exhibit higher levels of Senescent Cell Antigen Auto-Antibodies compared to normal, healthy persons.
Mercury toxicity can be an underlying cause of Autoimmune Diseases.
These Ailments Increase the Risk of Developing Autoimmune Diseases
The risk of developing Autoimmune Diseases increases in tandem with the progression of the Aging Process.
Hypochlorhydria can be an underlying cause of Autoimmune Diseases.
Intestinal Permeability increases the formation of Immune Complexes (which are involved in Autoimmune Diseases).
At least 10% of Vitiligo patients have evidence of another coexisting Autoimmune Disease.
Other Factors Contributing to Autoimmune Diseases
Immune System Cells
Excessive production of B-Lymphocytes increases the body's production of Auto-Antibodies.
Persons afflicted with Autoimmune Diseases generally have a HIGH Helper T-
Cells:Suppressor T-Cells ratio (i.e. an excess of Helper T-Cells compared to Suppressor T-Cells):
- Excessive activity of TH1 Helper T-Cells (known as TH1 Helper T-Cells Dominance) is involved in (organ-specific) Autoimmune Diseases.
- Excessive activity of TH2 Helper T-Cells (known as TH2 Helper T-Cells Dominance) is implicated in (systemic) Autoimmune Diseases (due to excessive stimulation of B-Lymphocytes by TH2 Helper T-Cells).
These Substances Exacerbate Autoimmune Diseases
Persons afflicted with Autoimmune Diseases should not use supplemental Melatonin (due to Melatonin's ability to further stimulate the already over-stimulated Immune System that is a characteristic of Autoimmune Diseases).
Persons afflicted with Autoimmune Diseases should not use Biostim (as Biostim can further stimulate an already over-stimulated Immune System).
Notes by David Arthur(B.Pharm MPS)